Biocatalytic access to betazole using a one-pot multienzymatic system in continuous flow
María Romero‐Fernández, Francesca Paradisi
Abstract
The primary amine of betazole is synthesised from an alcohol in a one-pot, continuous flow biocatalytic cascade, using a PBR hosting a multienzyme co-immobilised system with constant O<sub>2</sub> supply for <italic>in situ</italic> cofactor recycling, yielding 2.59 g L<sup>−1</sup> h<sup>−1</sup>.
Topics & Concepts
Amine gas treatingChemistryContinuous flowAlcoholCascadePrimary alcoholPrimary (astronomy)Organic chemistryFlow chemistryCofactorCombinatorial chemistryChromatographyCatalysisEnzymePhysicsMechanicsAstronomyInnovative Microfluidic and Catalytic Techniques InnovationEnzyme Catalysis and ImmobilizationAsymmetric Hydrogenation and Catalysis