CD44v3 protein-carrying tumor-derived exosomes in HNSCC patients’ plasma as potential noninvasive biomarkers of disease activity
Marie‐Nicole Theodoraki, Akihiro Matsumoto, Inga J. Beccard, Thomas K. Hoffmann, Theresa L. Whiteside
Abstract
< .005), and RFI values for these markers correlated with higher disease stages and lymph node metastasis. Isolation of CD44v3+ exosomes by immunocapture allowed for enrichment of TEX which are potentially promising liquid biomarkers of the tumor burden and disease stage in HNSCC.
Topics & Concepts
MicrovesiclesCancer researchFlow cytometryBiomarkerMetastasisAntibodyMedicinePlasma cellCancerImmunologyChemistryInternal medicinemicroRNABiochemistryGeneExtracellular vesicles in diseaseImmunotherapy and Immune ResponsesMicroRNA in disease regulation