Inhibition of Cholesterol Esterification Enzyme Enhances the Potency of Human Chimeric Antigen Receptor T Cells against Pancreatic Carcinoma
Lei Zhao, Yang Liu, Fuya Zhao, Jin Ye, Jing Feng, Rui Geng, Jiayu Sun, Liqing Kang, Lei Yu, Yunwei Wei
Abstract
observations. Our findings demonstrate a novel immunotherapeutic strategy involving the transplantation of ACAT-1-inhibited targeting MSLN CAR-T cells and the feasibility of enhancing the antitumor potency of CAR-T through the novel strategy.
Topics & Concepts
Chimeric antigen receptorCancer researchMesothelinCytotoxicityIn vivoAntigenIn vitroChemistryBiologyMolecular biologyPharmacologyT cellImmunologyImmune systemBiochemistryBiotechnologyCAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction