Sulfamate-Tethered Aza-Wacker Strategy for a Kasugamine Synthon
Gour Hari Mandal, Shyam Sathyamoorthi
Abstract
We present our preparation of a kasugamine synthon, which proceeds in 14 steps from a literature epoxide. We expect that this kasugamine derivative can be used for the total syntheses of kasugamycin, minosaminomycin, and analogue antibiotics. A key step in the synthesis is our laboratory's sulfamate-tethered aza-Wacker cyclization.
Topics & Concepts
SynthonWacker processChemistryComputer scienceStereochemistryBiochemistryCatalysisEthyleneSynthesis and Catalytic ReactionsSulfur-Based Synthesis TechniquesSynthetic Organic Chemistry Methods