EBV-associated epithelial cancers cells promote vasculogenic mimicry formation via a secretory cross-talk with the immune microenvironment
Tong Xiang, Fengze Sun, Tingting Liu, Jingjing Zhao, Jieying Yang, Dijun Ouyang, Hao Chen, Qian Zhu, Qi-jing Wang, Yong-qiang Li, Jia He, Chaopin Yang, Xinyi Yang, Yuanyuan Chen, Yan Tang, Desheng Weng, Qiuzhong Pan, Qi Yang, Jian‐Chuan Xia
Abstract
Our findings define a secretory cross-talk between tumour cells and the immune microenvironment in EBV-associated epithelial cancer, revealing an unexpected role of EBV in epithelial cancer cells, controlling VM formation via M2c-like macrophages.
Topics & Concepts
Vasculogenic mimicryImmune systemTumor microenvironmentImmunologyBiologyCancer researchMedicineCancerInternal medicineMetastasisViral-associated cancers and disordersCancer-related molecular mechanisms researchImmune Cell Function and Interaction