Withaferin A exerts an anti-obesity effect by increasing energy expenditure through thermogenic gene expression in high-fat diet-fed obese mice
Da-Hye Lee, So‐Hyun Park, Eunyoung Lee, Hyo‐Deok Seo, Jiyun Ahn, Young Jin Jang, Tae Youl Ha, Seung‐Soon Im, Chang Hwa Jung
Topics & Concepts
AMPKWithaferin AWhite adipose tissueMitochondrial biogenesisEndocrinologyInternal medicineProtein kinase AMAPK/ERK pathwayBrown adipose tissueUncoupling proteinAdipose tissueWithania somniferaThermogenesisp38 mitogen-activated protein kinasesThermogeninBiologyDiet-induced obeseKinaseMedicineCell biologyMitochondrionObesityPathologyAlternative medicineInsulin resistanceAdipokines, Inflammation, and Metabolic DiseasesPhytochemicals and Medicinal PlantsAdipose Tissue and Metabolism