Role of CB<sub>1</sub> receptors in the acute regulation of small intestinal permeability: effects of high-fat diet
Hailey Cuddihey, Jean‐Baptiste Cavin, Catherine M. Keenan, Laurie E. Wallace, Kiran Vemuri, Alexandros Makriyannis, Wallace K. MacNaughton, Keith A. Sharkey
2022American Journal of Physiology-Gastrointestinal and Liver Physiology17 citationsDOIOpen Access PDF
Abstract
The endocannabinoid system of the gastrointestinal tract regulates homeostasis by acting as brake on motility and secretion. Here we show that when exposed to a high fat diet, intestinal permeability is increased and activation of the CB 1 receptor on the intestinal epithelium restores barrier function. This work further highlights the role of the endocannabinoid system in regulating intestinal homeostasis when it is perturbed.
Topics & Concepts
Endocannabinoid systemIntestinal permeabilityHomeostasisReceptorMotilityIntestinal epitheliumSecretionInternal medicineGastrointestinal tractEndocrinologyBarrier functionBiologyChemistryCell biologyEpitheliumMedicineGeneticsCannabis and Cannabinoid ResearchDietary Effects on HealthBiochemical Analysis and Sensing Techniques