Increased FAPI Uptake in Brain Metastasis From Lung Cancer on 68Ga-FAPI PET/CT
Wenhui Fu, Lin Liu, Huipan Liu, Zhijun Zhou, Yue Chen
Abstract
A 51-year-old woman with newly diagnosed lung cancer experienced progressive left hip pain for 1 month. F-FDG PET/CT showed multiple hypermetabolic lesions throughout the body, including a suspicious lesion in the brain. Elevated FDG activity in select muscles was visualized, which was attributed to altered weight bearing. Unexpectedly, Ga-fibroblast activation protein inhibitor PET/CT showed the FDG-avid lesion in the brain with excellent imaging contrast. Brain metastasis was confirmed by a cerebral MRI.
Topics & Concepts
MedicineLesionLung cancerLungMetastasisNuclear medicinePET-CTPathologyCancerMagnetic resonance imagingFibroblast activation protein, alphaBrain metastasisRadiologyPositron emission tomographyInternal medicinePeptidase Inhibition and AnalysisProtease and Inhibitor MechanismsCardiac Structural Anomalies and Repair