Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle
Tai‐Yu Huang, Melissa A. Linden, Scott Fuller, Felicia Goldsmith, Jacob Simon, Heidi M. Batdorf, Matthew C. Scott, Nabil M. Essajee, John Brown, Robert C. Noland
Abstract
A ketogenic diet with normal protein content (NPKD) increases body weight and fat mass, increases intramuscular triglyceride storage, and upregulates pathways related to protein metabolism. In combination with exercise training, a NPKD induces additive and/or synergistic activation of AMPK, PGC-1α, mitochondrial fission/fusion genes, mitochondrial fatty acid oxidation, and peroxisomal adaptations in skeletal muscle. Collectively, results from this study provide mechanistic insight into adaptations in skeletal muscle relevant to keto-adaptation.
Topics & Concepts
PeroxisomeOxidative phosphorylationSkeletal muscleKetogenic dietMitochondrionSubstrate (aquarium)Internal medicineEndurance trainingEndocrinologyChemistryBiologyMedicineBiochemistryNeuroscienceEcologyEpilepsyReceptorAdipose Tissue and MetabolismDiet and metabolism studiesMitochondrial Function and Pathology