Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease
Artem A. Serganov, Yael Udi, Milana E. Stein, Valay Patel, Peter C. Fridy, Charles M. Rice, Mohsan Saeed, Erica Y. Jacobs, Brian T. Chait, Michael P. Rout
Abstract
selectively inhibits protein translation, key nuclear export pathways, and cellular mRNA localization early in infection to benefit viral replication at the expense of particular cell functions.
Topics & Concepts
PicornavirusProteasePrimary (astronomy)Computational biologyChemistryVirologyBiologyBiochemistryCell biologyEnzymeRNAPhysicsGeneAstronomyViral Infections and Immunology ResearchAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology