Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice
Hiroaki Eshima, Piyarat Siripoksup, Ziad S. Mahmassani, Jordan M. Johnson, Patrick J. Ferrara, Anthony R.P. Verkerke, Anahy Salcedo, Micah J. Drummond, Katsuhiko Funai
Abstract
The premise of this study was to examine the efficacy of genetic suppression of mitochondrial reactive oxygen species (ROS) to attenuate disuse-induced muscle atrophy and muscle weakness. Neutralization of mitochondrial ROS by MCAT expression was insufficient to rescue muscle atrophy and muscle weakness.
Topics & Concepts
Muscle atrophyAtrophyHindlimbReactive oxygen speciesMitochondrial ROSMitochondrionWeaknessBiologySkeletal muscleMuscle weaknessInternal medicineCell biologyAnatomyMedicineMuscle Physiology and DisordersAdipose Tissue and MetabolismExercise and Physiological Responses