Enantioselective Hydroxylation of Benzylic C(sp<sup>3</sup>)–H Bonds by an Artificial Iron Hydroxylase Based on the Biotin–Streptavidin Technology
Joan Serrano‐Plana, Corentin Rumo, Johannes G. Rebelein, Ryan L. Peterson, Maxime Barnet, Thomas R. Ward
Abstract
)-tetralol. X-ray analysis of artificial hydroxylases highlights critical details of the second coordination sphere around the Fe(TAML) cofactor.
Topics & Concepts
ChemistryHydroxylationStreptavidinBiotinylationCofactorCombinatorial chemistryKinetic resolutionEnantioselective synthesisLigand (biochemistry)BiocatalysisCatalysisStereochemistryBiotinEnzymeOrganic chemistryBiochemistryReceptorReaction mechanismMetal-Catalyzed Oxygenation MechanismsCO2 Reduction Techniques and CatalystsCyclopropane Reaction Mechanisms