Walnut-Derived Peptide Enhances Mitophagy via JNK-Mediated PINK1 Activation to Reduce Oxidative Stress in HT-22 Cells
Jingqi Yang, Li Fang, Hongyan Lu, Chunlei Liu, Ji Wang, Dan Wu, Weihong Min
Abstract
, caspase-9, and cleaved-caspase-3 expression. Additionally, BDNF and SNAP-25 levels significantly increased to protect the synaptic function. Collectively, TW-7 improved oxidative stress-mediated nerve cell injury via JNK-regulated PINK1-mediated mitophagy.
Topics & Concepts
Oxidative stressMitophagyReactive oxygen speciesPINK1Cell biologyChemistryMitochondrionMitochondrial permeability transition poreSuperoxide dismutaseSOD2ApoptosisMolecular biologyBiologyBiochemistryProgrammed cell deathAutophagyMitochondrial Function and PathologyAutophagy in Disease and TherapyTrace Elements in Health