Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model
David Falck, Martin Lechmann, Ana Momčilović, Marco Thomann, Carolien A. M. Koeleman, Cordula Jany, Sebastian Malik, Manfred Wuhrer, Dietmar Reusch
Abstract
- maximum serum concentration; CQA critical quality attribute; FcγR - Fc gamma receptor; IgG - immunoglobulin G; IV - intravenous; LC-MS - liquid chromatography - mass spectrometry; mAb - therapeutic monoclonal antibody; PK - pharmacokinetics; SC - subcutaneous; TMDD - target-mediated drug disposition.
Topics & Concepts
Monoclonal antibodyChemistryClearanceAntibodyPharmacokineticsSubcutaneous injectionGlycosylationPharmacologyClearance rateBiochemistryImmunologyInternal medicineMedicineUrologyMonoclonal and Polyclonal Antibodies ResearchProtein purification and stabilityT-cell and B-cell Immunology