Seeking potent anti-tubercular agents: design and synthesis of substituted-<i>N</i>-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
Singireddi Srinivasarao, Adinarayana Nandikolla, Amaroju Suresh, Kevin Van Calster, Linda De Voogt, Davie Cappoen, Balaram Ghosh, Himanshu Aggarwal, Sankaranarayanan Murugesan, Kondapalli Venkata Gowri Chandra Sekhar
Abstract
of 40.32 μM. Moreover, single crystals were developed for 6d, 6f and 6n. In addition, most active compounds were evaluated for their cytotoxicity on HEK-293 (human embryonic kidney) cells. Our results indicate that the compounds are nontoxic to human cells. The molecular interactions of the derivatised conjugates in docking studies reveal their suitability for further development.
Topics & Concepts
BenzamidePiperazineChemistryPyrazineCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistrySynthesis and biological activitySynthesis and Biological EvaluationSynthesis and Reactivity of Heterocycles