Small-molecule allosteric inhibitors of GPX4
Hengrui Liu, F. Forouhar, Annie Lin, Qian Wang, Vasiliki Polychronidou, Rajesh K. Soni, Xin Xia, Brent R. Stockwell
Topics & Concepts
Allosteric regulationSmall moleculeChemistryBinding siteActive siteAllosteric enzymeBiochemistryGPX4EnzymeGlutathioneBiophysicsBiologyGlutathione peroxidaseInflammatory mediators and NSAID effectsRedox biology and oxidative stressSteroid Chemistry and Biochemistry