Multimodal imaging approach to track theranostic nanoparticle accumulation in glioblastoma with magnetic resonance imaging and intravital microscopy
Giovanni Marco Saladino, Dilyana B. Mangarova, Kerem Nernekli, Jie Wang, Giacomo Annio, Zahra Shokri Varniab, Zubeda Khatoon, Goreti Ribeiro Morais, Yifeng Shi, Edwin Chang, Laura Pisani, Grigory Tikhomirov, Robert A. Falconer, Heike E. Daldrup‐Link
Abstract
observations. The presented multimodal imaging approach enabled a quantitative correlation between MRI contrast enhancement at the macroscopic level and NP accumulation in the tumor microenvironment. These studies lay the groundwork for the precise evaluation of the tumor targeting of theranostic NPs.
Topics & Concepts
Magnetic resonance imagingGlioblastomaIntravital microscopyNanoparticleMaterials scienceTrack (disk drive)Magnetic nanoparticlesNanotechnologyNuclear magnetic resonanceMicroscopyComputer scienceMedicineRadiologyPathologyPhysicsCancer researchOperating systemMicrocirculationNanoparticle-Based Drug DeliveryAdvanced Electron Microscopy Techniques and ApplicationsCharacterization and Applications of Magnetic Nanoparticles