Designing moringa gum-sterculia gum-polyacrylamide hydrogel wound dressings for drug delivery applications
Jasvir Singh, Vikrant Sharma, Rohit and Ajay Kumar
Abstract
Herein this manuscript the potential of moringa gum and sterculia gum polysaccharides has been explored for developing the hydrogel wound dressing for better wound care. The polysaccharide gum and polyacrylamide network structure was formed through grafting and crosslinking polymerization. The cryo-SEM and AFM of the films indicated the porosity in the polymer films and roughness of the polymer surface. The polymers were also characterized by FTIR, and 13C NMR studies. The release of the antibiotic drug levofloxacin from polymer dressings occurred with non-Fickian diffusion mechanism. The blood compatibility, wound fluid absorption, antioxidant activity, mucoadhesion and mechanical properties were evaluated along with O2 and H2O permeability. The drug released fitted in Korsmeyer-Peppas kinetic model. The hydrogel films were permeable to O2 and H2O vapor and impermeable to microbes in open environment and showed high wound fluid absorption, mucoadhesion and antioxidant activity.