Interaction between Host and Microbes in the Semen of Patients with Idiopathic Nonobstructive Azoospermia
Peigen Chen, Yanqing Li, Xinning Zhu, Menghui Ma, Haicheng Chen, Junxian He, Xiaoyan Liang, Guihua Liu, Xing Yang
Abstract
Idiopathic nonobstructive azoospermia is one of the great challenges in assisted reproductive therapy. Although microdissection testicular sperm extraction technology is currently available, many men with iNOA still face the problem of poor sperm retrieval and poor sperm quality. The role of seminal plasma microbes in male disease has been continuously investigated since semen was demonstrated to harbor commensal microbes. To our knowledge, this is the first detailed description of the microbe-host relationship in iNOA semen. This study is an important complement to research on the treatment and etiology of iNOA and the rationale for our ongoing research.