Canagliflozin ameliorates high glucose-induced apoptosis in NRK-52E cells via inhibiting oxidative stress and activating AMPK/mTOR-mediated autophagy
Hong Liu, Weidong Chen, Sheng Wan, Ye Chen, Mengjing Fu, Zengsi Wang, Fei Xiong, Yanmin Zhang
Topics & Concepts
AMPKCanagliflozinChemistryAutophagyPI3K/AKT/mTOR pathwayOxidative stressReactive oxygen speciesApoptosisNOX4Protein kinase ACell biologyPharmacologyPhosphorylationBiochemistryNADPH oxidaseBiologyEndocrinologyType 2 Diabetes MellitusDiabetes mellitusDiabetes Treatment and ManagementChronic Kidney Disease and DiabetesPancreatic function and diabetes