Essential Role of NLRP3 Inflammasome in Mediating IL-1β Production and the Pathobiology of Staphylococcus aureus Endophthalmitis
Ajay Kumar, Ajay Kumar, Pawan Kumar Singh, Zeeshan Ahmed, Sukhvinder Singh, Ashok Kumar, Ashok Kumar
Abstract
mice revealed that NLRP3 and IL-1β deficiency leads to increased intraocular bacterial burden and retinal tissue damage. Altogether, our study demonstrated an essential role of NLRP3 inflammasome activation in regulating innate immune responses in bacterial endophthalmitis.
Topics & Concepts
InflammasomeEndophthalmitisStaphylococcus aureusInnate immune systemImmunologyBiologyInflammationStaphylococcal infectionsMicrobiologyImmune systemImmunityBacteriaGeneticsInflammasome and immune disordersOcular Diseases and Behçet’s SyndromeNeutrophil, Myeloperoxidase and Oxidative Mechanisms