Protected amino acids as a nonbonding source of chirality in induction of single-handed screw-sense to helical macromolecular catalysts
Shoma Ikeda, Ryohei Takeda, Takaya Fujie, Naoto Ariki, Yuuya Nagata, Michinori Suginome
Abstract
Achiral poly(quinoxaline-2,3-diyl) containing Ar 2 P groups undergo dynamic induction of M -helical conformation through nonbonding interaction with protected AA such as Ac- l -Pro-OMe, serving as a chiral ligand in asymmetric cross-coupling with up to 95% ee.
Topics & Concepts
Chirality (physics)CatalysisMacromoleculeAsymmetric inductionSense (electronics)ChemistryStereochemistryCrystallographyPhysicsEnantioselective synthesisOrganic chemistryBiochemistryQuantum mechanicsPhysical chemistryChiral symmetryQuarkNambu–Jona-Lasinio modelSynthesis and Properties of Aromatic CompoundsSupramolecular Self-Assembly in MaterialsAxial and Atropisomeric Chirality Synthesis