Sex-Related Differences in Patient Characteristics, Hemodynamics, and Outcomes of Cardiogenic Shock: INOVA-SHOCK Registry
Kelly Epps, Behnam Tehrani, Carolyn Rosner, Pramita Bagchi, Annunziata Cotugno, Abdulla A. Damluji, Christopher R. deFilippi, Shashank Desai, Nasrien E. Ibrahim, Mitchell A. Psotka, Anika Raja, Matthew W. Sherwood, Ramesh Singh, Shashank S. Sinha, Daniel Tang, Alexander G. Truesdell, Christopher M. O’Connor, Wayne Batchelor
Abstract
Background: Little is known about sex-related differences in outcomes of patients with cardiogenic shock (CS) treated within a standardized team-based approach (STBA). Methods: We evaluated 520 consecutive patients (151 women and 369 men) with CS due to acute myocardial infarction (AMI) and heart failure (HF) in a single-center registry (January 2017-December 2019) and examined outcomes according to sex and CS phenotype. The primary outcome was in-hospital mortality. Secondary outcomes included major adverse cardiac events, 30-day mortality, major bleeding, vascular complications, and stroke. Results: = .01). However, female sex was not an independent predictor of these complications. No sex differences in survival were noted at 1 year. Conclusions: Within an STBA, although women with AMI-CS and HF-CS presented with higher acuity, they experienced similar in-hospital mortality, major adverse cardiac events, 30-day mortality, stroke, and 30-day readmissions as men. Further research is needed to better understand the extent to which historical differences in CS outcomes can be mitigated by an STBA.