Targeted delivery of maytansine to liver cancer cells <i>via</i> galactose-modified supramolecular two-dimensional glycomaterial
Haina Xie, Yu-Yuan Chen, Guo-Biao Zhu, Hai‐Hao Han, Xi‐Le Hu, Zhiqiang Pan, Yi Zang, Donghao Xie, Xiao‐Peng He, Jia Li, Tony D. James
Abstract
. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.
Topics & Concepts
Supramolecular chemistryGalactoseChemistryConjugateCytotoxicityLiver cancerCancer cellCombinatorial chemistryBiophysicsCancerNanotechnologyCancer researchBiochemistryMaterials scienceIn vitroMoleculeHepatocellular carcinomaOrganic chemistryMedicineBiologyInternal medicineMathematicsMathematical analysisGlycosylation and Glycoproteins ResearchSupramolecular Self-Assembly in MaterialsCarbohydrate Chemistry and Synthesis