Photocatalytic Synthesis of γ,γ-Difluoroallylic Ketones and δ,δ-Difluoroallylic Ketones via a Desulfurative/Defluorinative Alkylation Process
Yunqi Liu, Xiyan Zhou, Ruining Li, Zhankui Sun
Abstract
-difluoroalkene moiety is frequently found in medicinal chemistry. From α-keton sulfides and thioic acids, we were able to develop a universal approach for the synthesis of γ,γ-difluoroallylic ketones and δ,δ-difluoroallylic ketones via a desulfurative/defluorinative alkylation process. We expect that this mild and efficient method will be complementary to other known strategies.
Topics & Concepts
ChemistryAlkylationPhotocatalysisKetoneProcess (computing)Organic chemistryCombinatorial chemistryPhotochemistryCatalysisComputer scienceOperating systemFluorine in Organic ChemistryChemical Synthesis and AnalysisCarbohydrate Chemistry and Synthesis