The role of gut vascular barrier in experimental alcoholic liver disease and A. muciniphila supplementation
Christoph Grander, Felix Grabherr, Ilaria Spadoni, Barbara Enrich, Georg Oberhuber, María Rescigno, Herbert Tilg
Abstract
administration tended to restore GVB. To further investigate GVB in experimental ALD, β-catenin gain-of-function mice, which display an enhanced GVB, were ethanol-fed. β-catenin gain-of-function mice were not protected from ethanol-induced liver injury, suggest an alternative mechanism of ethanol-induced GVB disruption. The description of the GVB in ALD could pave the way for new therapeutic options in the future.
Topics & Concepts
Alcoholic liver diseaseBiologyPathogenesisBarrier functionImmunologyInternal medicineEndocrinologyMedicineCirrhosisCell biologyAlcohol Consumption and Health EffectsLiver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease