Modulation of two-dimensional palladium nanozyme activity to enhance chemodynamic/photothermal combined therapy for melanoma
Duo Sun, Kaijun Liu, Yi Cheng, Jinju Sun, Jingqin Fang, Yi Tang, Fangyang Wang, Yu Amanda Guo, Yi Wang, Xiao Chen
Abstract
to ˙OH. Impressively, the reactive oxygen species (ROS) generation of rGO-Pd was further remarkably enhanced by the endogenous acidity of the tumor microenvironment and the exogenous NIR light-responsive photothermal effect. These collective properties of the rGO-Pd nanozyme enabled it to be a ROS generation accelerator for photothermally enhanced tumor chemodynamic therapy. Thus, the as-developed rGO-Pd may represent a promising new type of high-performance nanozyme for multifunctional nanotheranostics toward cancer.
Topics & Concepts
Photothermal therapyPalladiumMelanomaModulation (music)Materials scienceCancer researchNanotechnologyChemistryMedicineBiochemistryCatalysisAestheticsPhilosophyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanocluster Synthesis and Applications