Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
Lea Marie Schatz, Alexander Brinkmann, Anka C. Röhr, Otto Frey, Sebastian Greppmair, Ferdinand Weinelt, Michael Zöller, Christina Scharf, Georg Hempel, Uwe Liebchen
Abstract
and Bayesian dosing MPE within |2%|, MAPE <30%). Our study revealed the O'Jeanson model as the best-predicting model for intermittent infusion. However, most of the selected PopPK models are suitable for MIPD in CRRT patients when one therapeutic drug monitoring sample is available.
Topics & Concepts
DosingMeropenemMedicineRenal replacement therapyPharmacokineticsKidney diseaseCritically illPopulationIntensive care medicineInternal medicineAntibioticsAntibiotic resistanceBiologyEnvironmental healthMicrobiologyAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory InfectionsHemodynamic Monitoring and Therapy