Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli
Michelle A. Wiebe, John R. Brannon, Bradley D. Steiner, Adebisi Bamidele, Alexandra C. Schrimpe‐Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Maria Hadjifrangiskou
Abstract
The observation that l-serine uptake occurs as E. coli cultures grow is well established, yet the benefit E. coli garners from this uptake remains unclear. Here, we report a novel acid tolerance mechanism where l-serine is deaminated to pyruvate and ammonia, promoting survival of E. coli under acidic conditions. This study is important as it provides evidence of the use of l-serine as an acid response strategy, not previously reported for E. coli.
Topics & Concepts
SerineDeaminationEscherichia coliBiochemistryTransporterBiologyChemistryPhosphorylationEnzymeGeneAmino Acid Enzymes and MetabolismEnzyme Structure and FunctionMetabolism and Genetic Disorders