CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation
Magdalena Billerhart, Monika Schönhofer, Hemma Schueffl, Wolfram Polzer, Julia Pichler, Simon Decker, Alexander Taschauer, Julia Maier, Martina Anton, Sebastian Eckmann, Manuel Blaschek, Petra Heffeter, Haider Sami, Manfred Ogris
Abstract
. Taken together, this approach also opens the opportunity to block, in principle, any immune checkpoints.
Topics & Concepts
Fusion proteinCD47CancerCancer researchMacrophageMedicineImmunologyBiologyImmune systemRecombinant DNAInternal medicineGeneIn vitroBiochemistryPhagocytosis and Immune RegulationImmunotherapy and Immune ResponsesImmune cells in cancer