The gut microbe-derived metabolite trimethylamine-N-oxide induces aortic valve fibrosis via PERK/ATF-4 and IRE-1α/XBP-1s signaling in vitro and in vivo
Zhenyu Xiong, Jiaying Li, Rihua Huang, Huimin Zhou, Xingfeng Xu, Shaozhao Zhang, Peihan Xie, Miaohong Li, Yue Leon Guo, Xinxue Liao, Xiaodong Zhuang
Topics & Concepts
In vivoMetaboliteTrimethylamine N-oxideIn vitroChemistryCell biologyFibrosisAortic valvePharmacologyMedicineBiologyTrimethylamineBiochemistryInternal medicineBiotechnologyEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyInflammasome and immune disorders