PROTAC-mediated CDK degradation differentially impacts cancer cell cycles due to heterogeneity in kinase dependencies
Vishnu Kumarasamy, Zhe Gao, Bosheng Zhao, Baishan Jiang, Seth M. Rubin, Kevin Burgess, Agnieszka K. Witkiewicz, Erik S. Knudsen
Topics & Concepts
PalbociclibCyclin-dependent kinaseCyclin-dependent kinase 6Restriction pointCyclin-dependent kinase 4Cell cycleCyclin-dependent kinase 2Cancer researchKinaseCell biologyCyclin-dependent kinase 1Cyclin ACell growthBiologyChemistryCellProtein kinase ABiochemistryCancerGeneticsMetastatic breast cancerBreast cancerProtein Degradation and InhibitorsAdvanced Breast Cancer TherapiesChromatin Remodeling and Cancer