USP11 facilitates colorectal cancer proliferation and metastasis by regulating IGF2BP3 stability.
Yayu Huang, Chang-mao Zhang, Yang-Bin Dai, Jianguang Lin, Na Lin, Zhongxin Huang, Tianwen Xu
Abstract
. IGF2BP3 was protected by USP11 from degradation via deubiquitination. The rescue experiments revealed that IGF2BP3 overexpression could effectively reverse the decrease in cell proliferation, migration, and invasion caused by USP11 knockdown. Therefore, USP11 might be involved in CRC tumorigenesis and development through a USP11-IGF2BP3 axis pathway, and USP11 overexpression might be a novel indicator for poor prognosis and a potential therapeutic target in CRC patients.
Topics & Concepts
Gene knockdownCancer researchCarcinogenesisMetastasisImmunohistochemistryCell growthColorectal cancerBiologyIn vivoCancerBlotUbiquitinCell cultureGeneImmunologyBiochemistryGeneticsUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism