Modular Assembly of Pyrrolo[3,4-<i>c</i>]isoquinolines through Rh-Catalyzed Cascade C–H Activation/Annulation of <i>O</i>-Methyl Aryloximes with Maleimides
Yinsong Wu, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Yongjia Shang, Xinwei He
Abstract
An efficient and practical strategy for the construction of pyrrolo[3,4- c ]isoquinolines via Rh(III)-catalyzed cascade C–H activation and subsequential annulation process from easily available O -methyl aryloximes and maleimides has been disclosed. This facile protocol does not require any inert atmosphere protection with good efficiency in a low loading of catalyst and exhibits good functional group tolerance and broad substrate scope. Notably, the as-prepared products show potential photophysical properties.
Topics & Concepts
ChemistryAnnulationStereochemistryCascadeCatalysisModular designOrganic chemistryComputer scienceOperating systemChromatographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms