Emodin reverses 5-Fu resistance in human colorectal cancer via downregulation of PI3K/Akt signaling pathway.
Tonghu Li, Wenjun Si, Jiameng Zhu, Yin Li, Chongyang Zhong
Abstract
BACKGROUND: 5-Fu resistance is a major obstacle in the treatment of malignant tumors. Therefore, combination therapy is employed to overcome this limitation. Since it was demonstrated that emodin could resensitize breast cancer to 5-Fu treatment, we aimed to investigate if emodin could reverse 5-Fu resistant colorectal cancer (CRC) in the current study. METHODS: . RESULTS: study indicated that emodin could notably reverse 5-Fu resistance in CRC xenograft. CONCLUSION: . Thus, this finding might provide a molecular basis for treating 5-Fu resistant CRC.
Topics & Concepts
EmodinProtein kinase BPI3K/AKT/mTOR pathwayApoptosisDownregulation and upregulationCancer researchFlow cytometryCell growthIn vivoChemistryCell culturePharmacologyMedicineMolecular biologyBiologyBiochemistryGeneBiotechnologyGeneticsPhytochemistry and biological activity of medicinal plantsBioactive Compounds and Antitumor AgentsToxin Mechanisms and Immunotoxins