Amnestic MCI in ADNI
Kevin Duff, on behalf of the ADNI investigators
Abstract
Mild cognitive impairment (MCI), especially the amnestic subtype, has been proposed as a prodromal phase of Alzheimer disease (AD), where the patient has memory deficits but no/minimal functional impairment.1 Clinically, the demarcation point for memory deficits in MCI has typically been 1–1.5 SD units below normative data.1,2 Much of what we know about MCI has come from findings from the Alzheimer's Disease Neuroimaging Initiative (ADNI) studies.3
Topics & Concepts
Cognitive impairmentNeuroimagingMemory impairmentNormativePsychologyAlzheimer's diseaseAlzheimer's Disease Neuroimaging InitiativeDiseaseMedicineCognitionNeuroscienceInternal medicinePhilosophyEpistemologyDementia and Cognitive Impairment ResearchFunctional Brain Connectivity StudiesAlzheimer's disease research and treatments