Unlocking the Potential: immune functions of oligodendrocyte precursor cells
Amr Haroon, Harsha Seerapu, Li‐Pao Fang, Jakob Heinrich Weß, Xianshu Bai
Abstract
Oligodendrocyte precursor cells (OPCs) have long been regarded as progenitors of oligodendrocytes, yet recent advances have illuminated their multifaceted nature including their emerging immune functions. This review seeks to shed light on the immune functions exhibited by OPCs, spanning from phagocytosis to immune modulation and direct engagement with immune cells across various pathological scenarios. Comprehensive understanding of the immune functions of OPCs alongside their other roles will pave the way for targeted therapies in neurological disorders.
Topics & Concepts
Immune systemNeuroscienceOligodendrocyteBiologyImmune modulationPhagocytosisImmunologyCell biologyMyelinCentral nervous systemNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancer