CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway
Shixin Chan, Xu Wang, Zhenglin Wang, Youwen Du, Xiaomin Zuo, Jiajie Chen, Rui Sun, Qing Zhang, Lin Li, Yang Yang, Zhen Yu, Hu Zhao, Huabing Zhang, Wei Chen
Abstract
Akt/mTOR/Bcl2-mediated anti-apoptotic signaling inactivation, and CTSG represents a potential therapeutic target in CRC.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BCancer researchGene silencingBiologyCarcinogenesisSignal transductionApoptosisCancerIn vivoColorectal cancerCell biologyGeneGeneticsPI3K/AKT/mTOR signaling in cancerColorectal Cancer Treatments and StudiesCancer-related Molecular Pathways