Exosomal miR‑194 from adipose‑derived stem cells impedes hypertrophic scar formation through targeting TGF‑β1
Zhishan Xu, Yuan Tian, Lijun Hao
Abstract
evidence strongly supported the role of miR‑194 in attenuating hypertrophic scar formation through the suppression of TGF‑β1. The present study endorsed the strategic use of ADSCs‑Exos, particularly through miR‑194 modulation, as an effective strategy for reducing scar formation and lowering pro‑inflammatory and fibrotic indicators such as TGF‑β1. Therefore, the present study advocated the targeted application of ADSCs‑Exos, with an emphasis on miR‑194 modulation, as a promising approach to managing proliferative scarring.
Topics & Concepts
OncogeneAdipose tissueStem cellMolecular medicineCell cycleCancer researchBiologyCell biologyTransforming growth factorHypertrophic scarCellPathologyMedicineEndocrinologyGeneticsDermatologic Treatments and ResearchDiagnosis and Treatment of Venous Diseases