Exosomal circular RNAs: Biogenesis, effect, and application in cardiovascular diseases
Xiaoyi Hu, Hongran Qin, Yi Yan, Wenhui Wu, Su‐Gang Gong, Lan Wang, Rong Jiang, Qin‐Hua Zhao, Yuanyuan Sun, Qian Wang, Shang Wang, Hui Zhao, Jinming Liu, Ping Yuan
Abstract
modulation of its components, including circular RNAs (circRNAs). CircRNAs are a novel class of closed-loop single-stranded RNAs with a wide distribution, and play diverse biological roles. Due to its stability in exosomes, exosomal circRNAs serve as biomarkers, pathogenic regulators and exert therapeutic potentials in some cardiovascular diseases, including atherosclerosis, acute coronary syndrome, ischemia/reperfusion injury, heart failure, and peripheral artery disease. In this review, we detailed the current knowledge on the biogenesis and functions of exosomes, circRNAs, and exosomal circRNAs, as well as their involvement in these cardiovascular diseases, providing novel insights into the diagnosis and treatment of these diseases.