Solanimycin: Biosynthesis and Distribution of a New Antifungal Antibiotic Regulated by Two Quorum-Sensing Systems
Miguel A. Matilla, Rita E. Monson, Annabel C. Murphy, Muriel Leandra Schicketanz, Alison Rawlinson, Caia D. S. Duncan, Juan Mata, Finian J. Leeper, George P. C. Salmond
Abstract
spp., we provide further support for the potential of plant-associated bacteria for the biosynthesis of novel antimicrobials. The complex regulatory networks involved in solanimycin production reflect the high metabolic cost of bacterial secondary metabolism. This metabolic regulatory control makes many antibiotics cryptic under standard laboratory conditions, and mimicking environmental conditions, as shown here, is a strategy to activate cryptic antibiotic clusters.
Topics & Concepts
Quorum sensingNonribosomal peptideBiologyGene clusterHuman pathogenPolyketide synthaseMicrobiologyGenePathogenPolyketideAntimicrobialComputational biologyBiosynthesisVirulenceBiochemistryPlant-Microbe Interactions and ImmunityMicrobial Natural Products and BiosynthesisPlant Pathogens and Fungal Diseases