Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using (<sup>89</sup>Zr)-DFO- Galectin3-F(ab')<sub>2</sub> mAb
Zohreh Varasteh, Francesco De Rose, Sarajo K. Mohanta, Yuanfang Li, Xi Zhang, Benedikt Miritsch, Giorgia Scafetta, Changjun Yin, Hendrik B. Sager, Sarah Glasl, Dimitris Gorpas, Andreas J. R. Habenicht, Vasilis Ntziachristos, Wolfgang Weber, Armando Bartolazzi, Markus Schwaiger, Calogero D’Alessandria
Abstract
mAb PET/CT is a potentially novel tool to image atherosclerotic plaques at different stages of development, allowing knowledge-based tailored individual intervention in clinically significant disease.
Topics & Concepts
ImmunostainingCD68In vivoPathologyChemistryMolecular biologyGalectin-3Apolipoprotein EImmunohistochemistryMedicineBiologyBiotechnologyDiseaseGalectins and Cancer BiologyProtein Tyrosine PhosphatasesAtherosclerosis and Cardiovascular Diseases