Mice deficient in GM1 manifest both motor and non-motor symptoms of Parkinson's disease; successful treatment with synthetic GM1 ganglioside
Gusheng Wu, Zihua Lu, Joon Ho Seo, Samar K. Alselehdar, Shawn DeFrees, Robert W. Ledeen
Topics & Concepts
Parkinson's diseaseGangliosideNeuroscienceDiseaseMedicineMotor systemPsychologyInternal medicineBiologyGeneticsParkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders ResearchCellular transport and secretion