Discovery of a photoactivatable dimerized STING agonist based on the benzo[<i>b</i>]selenophene scaffold
Dongyu Liu, Bin Yu, Xin‐Yuan Guan, Bin Song, Huikai Pan, Renbing Wang, Xi Feng, Lixia Pan, Huidan Huang, Zhe Wang, Hongxi Wu, Zhixia Qiu, Zhiyu Li, Jinlei Bian
Abstract
anticancer activity was also proven with caged-diBSP01 in a zebrafish xenograft model. Our study provides insights into developing novel STING agonists for cancer treatment and a solution for precise STING activation to avoid the on-target systemic inflammatory response responsible for normal cell damage caused by systemic STING agonism.
Topics & Concepts
StingChemistryAgonistScaffoldStereochemistryComputer scienceReceptorPhysicsBiochemistryProgramming languageThermodynamicsinterferon and immune responsesATP Synthase and ATPases ResearchImmune Response and Inflammation