Time above the MIC of Piperacillin-Tazobactam as a Predictor of Outcome in Pseudomonas aeruginosa Bacteremia
Elias Tannous, Shelly Lipman, Antonella Tonna, Emma E. Hector, Ziad Hussein, Michal Stein, Sharon Reisfeld
Abstract
Pseudomonas aeruginosa bacteremia is an infection associated with a high mortality rate. Piperacillin-tazobactam is a β-lactam–β-lactamase inhibitor combination that is frequently used for the management of Pseudomonas aeruginosa infections. The pharmacokinetic-pharmacodynamic index associated with in vitro maximal bacterial killing for piperacillin-tazobactam is the percentage of the time between doses at which the free fraction concentration remains above the MIC (% fT >MIC ).
Topics & Concepts
PiperacillinPseudomonas aeruginosaPiperacillin/tazobactamTazobactamBacteremiaMicrobiologyPharmacodynamicsMedicinePharmacokineticsAntibioticsBiologyInternal medicineBacteriaGeneticsAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in BacteriaAntibiotic Use and Resistance