Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms
Jian Li, Jina Sun, Xianglei Zhang, Ruxue Zhang, Qian Wang, Lin Wang, Leike Zhang, Xiong Xie, Chunpu Li, Yu Zhou, Jiang Wang, Gengfu Xiao, Fang Bai, Hong Liu
Abstract
values with promising anti-SARS-CoV-2 activities. Further explorations with computational methodologies and experimental validations indicated that these macrocycles exert antiviral effects through binding with the N protein of SARS-CoV-2.
Topics & Concepts
MaleimidePeptidomimeticDruggabilityCombinatorial chemistryChemistryPeptideSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Organic chemistryBiochemistryInfectious disease (medical specialty)DiseaseMedicineGenePathologyChemical Synthesis and AnalysisClick Chemistry and ApplicationsAntimicrobial Peptides and Activities