Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling
Avijit Mallick, Ayush Ranawade, Wouter van den Berg, Bhagwati P. Gupta
Abstract
extends life span, delays muscle aging, and improves mitochondrial morphology in AAK-2-DAF-16-dependent manner. Furthermore, PRY-1 is necessary for AAK-2 phosphorylation. Taken together, our data demonstrate that PRY-1 functions in muscles to promote the life span of animals. This study establishes Axin as a major regulator of muscle health and aging.
Topics & Concepts
Caenorhabditis elegansBiologyAMPKRegulatorCell biologyPhosphorylationKinaseProtein kinase AGeneGeneticsGenetics, Aging, and Longevity in Model OrganismsFOXO transcription factor regulationGDF15 and Related Biomarkers