A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin
Maya Lipinsky, William S. Tobelaim, Asher Peretz, Luba Simhaev, Adva Yeheskel, Daniel Yakubovich, Guy L. LeBel, Yoav Paas, Joel A. Hirsch, Bernard Attali
Abstract
A unique mechanism of Kv7.1 inactivation is controlled by external Ca2 + and allosterically coupled by PIP2 and calmodulin.
Topics & Concepts
GatingCalmodulinBiophysicsPotassium channelChemistryAllosteric regulationMembrane potentialBiochemistryBiologyReceptorEnzymeIon channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research