Porcine circovirus type 2 infection attenuates the K63-linked ubiquitination of STING to inhibit IFN-β induction via p38-MAPK pathway
Xingchen Wu, Zhenyu Wang, Dan Qiao, Yu Yuan, Cong Han, Nan Yang, Ruizhen Li, Qian Du, Dewen Tong, Yong Huang
Topics & Concepts
IRF3StingTANK-binding kinase 1BiologyPorcine circovirusPhosphorylationUbiquitinSignal transductionGene knockdownp38 mitogen-activated protein kinasesSTAT1VirologyMAPK/ERK pathwayCell biologyImmunologyImmune systemCell cultureVirusInnate immune systemGeneBiochemistryAerospace engineeringGeneticsMAP kinase kinase kinaseEngineeringinterferon and immune responsesAnimal Virus Infections StudiesViral Infections and Vectors