Decoding the function of the human glycome using chemical glycoprobes and glycosensor arrays
Xiao-Peng He
Abstract
pathogens and cancer cells) assisted by dimension-reduction analyses. These studies have advanced basic glycobiological research as well as disease diagnosis and therapy. This tutorial review highlights a selection of examples relevant to this interdisciplinary research area and proposes future directions anticipated to make the functional decoding of the human glycome more effective, thus facilitating precision medicine.
Topics & Concepts
GlycomeComputational biologyFunction (biology)Human diseaseDECIPHERGlycanBiologyDecoding methodsHuman breastAmbiguityHuman liverSelection (genetic algorithm)ChemistryBioorthogonal chemistryComputer scienceHuman genomeGlycomicsComplement (music)Human bloodHuman proteinsChemical spaceBiochemistryCancerHuman healthMolecular Sensors and Ion DetectionGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis